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FLASH GENE
Symbol TFG contributors: mct - updated : 01-02-2012
HGNC name TRK-fused gene
HGNC id 11758
Corresponding disease
HMSNP hereditary motor and sensory neuropathy, proximal
Location 3q12.3      Physical location : 100.428.133 - 100.467.810
Synonym name
  • TRKT3 oncogene
  • protein TFG
  • Synonym symbol(s) TF6, TRKT3, FLJ36137
    DNA
    TYPE functioning gene
    STRUCTURE 39.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    SIAT10 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) ESDN 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) COL8A1 3q12-q13.1 collagen, type VIII, alpha 1 LOC389139 3 LOC389139 MGC4308 3q12.3 hypothetical protein MGC4308 DOC1 3q12.2 hypothetical protein MGC4308 PRO0641 3q12.3 PRO0641 protein LOC391559 3 hypothetical gene supported by BC003142; NM_006370 FLJ11046 3q12.3 hypothetical protein FLJ11046 NIT2 3q12.3 hypothetical protein FLJ11046 TOMM70A 3q11-q13.1 translocase of outer mitochondrial membrane 70 homolog A (yeast) FLJ10134 3q12.3 hypothetical protein FLJ10134 GPR128 3q12.3 G protein-coupled receptor 128 TFG 3q11-q12 TRK-fused gene TARSH 3q12 target of Nesh-SH3 IMPG2 3q12.2-q12.3 interphotoreceptor matrix proteoglycan 2 SENP7 3q12 interphotoreceptor matrix proteoglycan 2 LOC131909 3q12.3 similar to hypothetical protein FLJ20432 3q12.3 hypothetical protein FLJ20432 PCNP 3q12.3 PEST-containing nuclear protein LOC391560 3 similar to 60S ribosomal protein L32 ZNF-U69274 3q12.3 zinc finger protein RPL24 3cen-q11 ribosomal protein L24 LOC285359 3q12.3 hypothetical protein FLJ12205 FLJ23047 3q12.3 hypothetical protein FLJ23047 MGC15606 3q12.3 hypothetical protein MGC15606 MAIL 3p12-q12 molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse LOC131368 3q13.11 hypothetical protein LOC131368
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1841 - 400 - 1997 9169129
    8 - 2090 - 400 - 1997 9169129
    8 - 2078 - 396 - 1997 9169129
    8 - 1746 - 400 - 1997 9169129
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil region homolog to the N terminus of EWS and FUS, coiled-coil domain responsible for TRK-T3 oligomerization ; and has been previously identified in chromosome translocation events involving two protein kinases, which created a pair of oncogenes
  • one SPYGQ-rich region
  • octicosapeptide repeats
  • HOMOLOGY
    interspecies homolog to murine Tfg
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • able to modulate PTPN6 activity
  • enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity
  • target of chromosome translocations in lymphoma and soft tissue tumors, fused to GPR128 in healthy individuals
  • is localized in the cytoplasm, and likely modulates alternative splicing indirectly
  • putative metastatic melanoma tumor suppressor gene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    potential novel member of the NF-kappaB pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates and regulates the activity of the tyrosine phosphatase PTPN6
  • regulator of protein secretion that interacts directly with SEC16A
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • HNRNPH1 and TFG modulate the splicing activity of RBFOX1/2, whereas RALY had no effect
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMSNP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma
    ANIMAL & CELL MODELS