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FLASH GENE

Symbol

TFG

contributors: mct - updated : 03-01-2019

HGNC name	TRK-fused gene
HGNC id	11758

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HMSNP hereditary motor and sensory neuropathy, proximal SPG57 spastic paraplegia 57
Location	3q12.3      Physical location : 100.428.133 - 100.467.810
Synonym name	TRKT3 oncogene
	protein TFG
Synonym symbol(s)	TF6, TRKT3, FLJ36137, HMSNP, SPG57, TFG1

DNA

TYPE	functioning gene
STRUCTURE	39.68 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001007565 8 - 1841 NP_001007566 - 400 - 1997 9169129 NM_006070 8 - 2090 NP_006061 - 400 - 1997 9169129 NM_001195479 8 - 2078 NP_001182408 - 396 - 1997 9169129 NM_001195478 8 - 1746 NP_001182407 - 400 - 1997 9169129

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Endocrine pancreas       highly Nervous brain       highly Homo sapiens   brain hindbrain pons     Homo sapiens   brain midbrain nuclei     Homo sapiens   spinal cord anterior horn       Homo sapiens Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal coiled-coil region homolog to the N terminus of EWS and FUS, coiled-coil domain responsible for TRK-T3 oligomerization ; and has been previously identified in chromosome translocation events involving two protein kinases, which created a pair of oncogenes
	one SPYGQ-rich region
	octicosapeptide repeats

HOMOLOGY

interspecies

homolog to murine Tfg

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	localized at endoplasmic reticulum (ER) exit sites

basic FUNCTION	able to modulate PTPN6 activity
	enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity
	target of chromosome translocations in lymphoma and soft tissue tumors, fused to GPR128 in healthy individuals
	is localized in the cytoplasm, and likely modulates alternative splicing indirectly
	putative metastatic melanoma tumor suppressor gene
	TFG plays a pivotal role in negative regulation of RNA-sensing, DDX58-like receptor (RLR) family signaling pathways
	proline/glutamine-rich domain in TFG was critical for regulation of the ubiquitin-proteasome system (UPS) and proper localization at ER exit sites
	TFG functions at the ER/ERGIC interface to locally concentrate COPII-coated transport carriers and link exit sites on the ER to ERGIC membranes
	is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER
	reported to be involved in the regulation of cell size, apoptosis, cell growth, ER-Golgi protein secretion, NFKB1 pathway signaling, the ubiquitin-proteasome system, and pancreatic beta-cell mass and function
	key role for TFG-mediated protein transport in the pathogenesis of hereditary spastic paraplegia (HSP)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

potential novel member of the NF-kappaB pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	associates and regulates the activity of the tyrosine phosphatase PTPN6
	regulator of protein secretion that interacts directly with SEC16A
	HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
	HNRNPH1 and TFG modulate the splicing activity of RBFOX1/2, whereas RALY had no effect
	TFG plays likely a pivotal role in negative regulation of RNA-sensing, DDX58 family signaling pathways
	TFG is an inhibitory regulator of the UPS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HMSNP , SPG57

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma

ANIMAL & CELL MODELS