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FLASH GENE
Symbol TFG contributors: mct - updated : 03-01-2019
HGNC name TRK-fused gene
HGNC id 11758
Corresponding disease
HMSNP hereditary motor and sensory neuropathy, proximal
SPG57 spastic paraplegia 57
Location 3q12.3      Physical location : 100.428.133 - 100.467.810
Synonym name
  • TRKT3 oncogene
  • protein TFG
  • Synonym symbol(s) TF6, TRKT3, FLJ36137, HMSNP, SPG57, TFG1
    DNA
    TYPE functioning gene
    STRUCTURE 39.68 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    SIAT10 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) ESDN 3q12.2 sialyltransferase 10 (alpha-2,3-sialyltransferase VI) COL8A1 3q12-q13.1 collagen, type VIII, alpha 1 LOC389139 3 LOC389139 MGC4308 3q12.3 hypothetical protein MGC4308 DOC1 3q12.2 hypothetical protein MGC4308 PRO0641 3q12.3 PRO0641 protein LOC391559 3 hypothetical gene supported by BC003142; NM_006370 FLJ11046 3q12.3 hypothetical protein FLJ11046 NIT2 3q12.3 hypothetical protein FLJ11046 TOMM70A 3q11-q13.1 translocase of outer mitochondrial membrane 70 homolog A (yeast) FLJ10134 3q12.3 hypothetical protein FLJ10134 GPR128 3q12.3 G protein-coupled receptor 128 TFG 3q11-q12 TRK-fused gene TARSH 3q12 target of Nesh-SH3 IMPG2 3q12.2-q12.3 interphotoreceptor matrix proteoglycan 2 SENP7 3q12 interphotoreceptor matrix proteoglycan 2 LOC131909 3q12.3 similar to hypothetical protein FLJ20432 3q12.3 hypothetical protein FLJ20432 PCNP 3q12.3 PEST-containing nuclear protein LOC391560 3 similar to 60S ribosomal protein L32 ZNF-U69274 3q12.3 zinc finger protein RPL24 3cen-q11 ribosomal protein L24 LOC285359 3q12.3 hypothetical protein FLJ12205 FLJ23047 3q12.3 hypothetical protein FLJ23047 MGC15606 3q12.3 hypothetical protein MGC15606 MAIL 3p12-q12 molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse LOC131368 3q13.11 hypothetical protein LOC131368
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1841 - 400 - 1997 9169129
    8 - 2090 - 400 - 1997 9169129
    8 - 2078 - 396 - 1997 9169129
    8 - 1746 - 400 - 1997 9169129
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Endocrinepancreas   highly
    Nervousbrain   highly Homo sapiens
     brainhindbrainpons   Homo sapiens
     brainmidbrainnuclei   Homo sapiens
     spinal cordanterior horn    Homo sapiens
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal coiled-coil region homolog to the N terminus of EWS and FUS, coiled-coil domain responsible for TRK-T3 oligomerization ; and has been previously identified in chromosome translocation events involving two protein kinases, which created a pair of oncogenes
  • one SPYGQ-rich region
  • octicosapeptide repeats
  • HOMOLOGY
    interspecies homolog to murine Tfg
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localized at endoplasmic reticulum (ER) exit sites
  • basic FUNCTION
  • able to modulate PTPN6 activity
  • enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity
  • target of chromosome translocations in lymphoma and soft tissue tumors, fused to GPR128 in healthy individuals
  • is localized in the cytoplasm, and likely modulates alternative splicing indirectly
  • putative metastatic melanoma tumor suppressor gene
  • proline/glutamine-rich domain in TFG was critical for regulation of the ubiquitin-proteasome system (UPS) and proper localization at ER exit sites
  • TFG functions at the ER/ERGIC interface to locally concentrate COPII-coated transport carriers and link exit sites on the ER to ERGIC membranes
  • is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER
  • reported to be involved in the regulation of cell size, apoptosis, cell growth, ER-Golgi protein secretion, NFKB1 pathway signaling, the ubiquitin-proteasome system, and pancreatic beta-cell mass and function
  • key role for TFG-mediated protein transport in the pathogenesis of hereditary spastic paraplegia (HSP)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    potential novel member of the NF-kappaB pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates and regulates the activity of the tyrosine phosphatase PTPN6
  • regulator of protein secretion that interacts directly with SEC16A
  • HNRNPH1, RALY, and TFG are proteins that specifically interact with the C-terminal domain of RBFOX1 and RBFOX2
  • HNRNPH1 and TFG modulate the splicing activity of RBFOX1/2, whereas RALY had no effect
  • TFG plays likely a pivotal role in negative regulation of RNA-sensing, DDX58 family signaling pathways
  • TFG is an inhibitory regulator of the UPS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HMSNP , SPG57
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma
    ANIMAL & CELL MODELS