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FLASH GENE
Symbol CNIH4 contributors: mct - updated : 11-02-2011
HGNC name cornichon homolog 4 (Drosophila)
HGNC id 25013
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cornichon family
    • CATEGORY chaperone/stress , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text display a restricted distribution and are much less abundant than CACNG2
    basic FUNCTION
  • part of conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins
  • acting as chaperones for other proteins
  • can affect the trafficking of AMPARS (GRIA1, GRIA2, GRIA3, and GRIN2B), they were not detected on the surface of neurons and failed to alter the kinetics of endogenous AMPARs
  • can modestly enhance the surface expression of AMPARs in neurons, in the absence of CACNG2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS