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FLASH GENE

Symbol

CNIH4

contributors: mct - updated : 11-02-2011

HGNC name	cornichon homolog 4 (Drosophila)
HGNC id	25013

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014184 5 - 651 NP_054903 - 139 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

cornichon family

CATEGORY

chaperone/stress , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	display a restricted distribution and are much less abundant than CACNG2

basic FUNCTION	part of conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins
	acting as chaperones for other proteins
	can affect the trafficking of AMPARS (GRIA1, GRIA2, GRIA3, and GRIN2B), they were not detected on the surface of neurons and failed to alter the kinetics of endogenous AMPARs
	can modestly enhance the surface expression of AMPARs in neurons, in the absence of CACNG2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS