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FLASH GENE

Symbol

TEC

contributors: mct/npt - updated : 12-10-2009

HGNC name	tec protein tyrosine kinase
HGNC id	11719

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	134.01 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003215 18 - 3620 NP_003206 73.6 631 - Sato, Zemans (2009)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens Endocrine adrenal gland       highly   neuroendocrine pituitary     highly Respiratory respiratory tract larynx

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Homo sapiens Digestive hepatocyte Homo sapiens

cell lineage	hemocytopoietic cell lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a pleckstrin homology (PH)
	a SH2, a SH3 domains (SRC family, Tec subfamily)
	a BTK-type zinc finger
	a protein kinase domain

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	Tyr protein kinase family
	TEC subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in T cell activation
	involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules
	playing an essential role in phospholipase Cgamma (PLCgamma) activation following antigen receptor stimulation
	regulate activation of the MAPKs in other cell systems, and may be an upstream component of the signaling pathway leading to LPS-induced MAPKs activation in neutrophils (Zemans 2009)
	principal kinase of the Tec family that plays a major role in the responses of neutrophils to monosodium urate monohydrate crystals, which are likely to be involved in the initiation and perpetuation of gout (Popa-Nita 2008)
	may regulate hepatocyte differentiation and is involved in HGF signaling
	promotes the Erk-MAPK signaling pathway and acts downstream of MEK1 kinase but upstream of ERK kinase in HGF signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 zinc ion per subunit

protein	with CD28 receptor
	with SHIP1 and SHIP2

cell & other

REGULATION

activated by

CD3 or CD28

inhibited by

SHIP1 and SHIP2 (inhibition of its membrane localization)

Other	activated during liver regeneration
	upregulated during carly phase of liver regeneration

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in myelodysplastic syndrome tumoral fusion       with TAF15 in extraskeletal myxoid chondrosarcoma (Kim 2008)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS