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FLASH GENE
Symbol TGM1 contributors: mct - updated : 28-09-2013
HGNC name transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
HGNC id 11777
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
 pharynx   lowly
Lymphoid/Immunethymus   moderately
Reproductivefemale systemplacenta  moderately
 female systemuteruscervix moderately
 female systemuterus  lowly
Respiratoryrespiratory tracttrachea  lowly
 respiratory tractlarynx  predominantly
Urinarybladder   moderately
 kidney   lowly
Visualeye   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialbarrier liningretinal pigment epithelium (RPE) lowly
Muscularstriatumskeletal lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
Text umbilical cord at an highly level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • unique N terminal
  • C terminal extensions
    • HOMOLOGY
    interspecies homolog to dog TGM1 (92.26 pc)
    homolog to chimpanzee TGM1 (99.63 pc)
    homolog to rattus Tgm1 (91.52 pc)
    homolog to murine Tgm1 (91.49 pc)
    intraspecies homolog to clotting factor FXIII catalytic subunit
    Homologene
    FAMILY transglutaminase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text membrane bound
    basic FUNCTION
  • transglutaminase, crosslinking the structural components (SPRRs,IVL and LOR) and constituents of cornified enveloppe
  • also binding omega-hydroxyceramides to evolucrin by ester bond formation in the terminal step of the differentiation programme of epidermal keratinocytes
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCI1 , BSI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS