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FLASH GENE
Symbol HSPBP1 contributors: mct - updated : 08-01-2015
HGNC name HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HGNC id 24989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast Fes1
Homologene
FAMILY Hsp70 co-chaperone family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • nucleotide exchange factors that exhibit varying degrees of compartment and species specificity
  • extracellular HSPBP1 and HSPA1A synergistically activate epidermal growth factor receptor
  • may play a role in tumor (dys)regulation of chaperone proteins, and HSPBP1 may have extracellular roles with therapeutic implications
  • HSPBP1 and BAG-1M differentially regulate steroid hormone receptor function
  • affects chaperone expression at a posttranslational level by inhibiting the ubiquitylation and proteasomal degradation of inducible HSP70 proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between HSBP1 and the ATPase domain of the major heat shock protein HSPA4 up-regulates nucleotide exchange and reduces the affinity between HSPA4 and the peptide in its peptide-binding site
  • HSPBP1 incapacitates the HSPA4-PGLYRP1 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • male Hspbp1(-/-) mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes