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FLASH GENE

Symbol

HSPBP1

contributors: mct - updated : 08-01-2015

HGNC name	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HGNC id	24989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012267 8 - 1925 NP_036399 - 359 - 2006 16677834 NM_001130106 9 - 1816 NP_001123578 - 359 - 2006 16677834 NM_001297600 - - 1715 NP_001284529 - 405 - 2006 16677834

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Reproductive male system prostate       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to yeast Fes1

Homologene

FAMILY

Hsp70 co-chaperone family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	nucleotide exchange factors that exhibit varying degrees of compartment and species specificity
	extracellular HSPBP1 and HSPA1A synergistically activate epidermal growth factor receptor
	may play a role in tumor (dys)regulation of chaperone proteins, and HSPBP1 may have extracellular roles with therapeutic implications
	HSPBP1 and BAG-1M differentially regulate steroid hormone receptor function
	affects chaperone expression at a posttranslational level by inhibiting the ubiquitylation and proteasomal degradation of inducible HSP70 proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between HSBP1 and the ATPase domain of the major heat shock protein HSPA4 up-regulates nucleotide exchange and reduces the affinity between HSPA4 and the peptide in its peptide-binding site
	HSPBP1 incapacitates the HSPA4-PGLYRP1 complex

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

male Hspbp1(-/-) mice are sterile because of impaired meiosis and massive apoptosis of spermatocytes