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FLASH GENE
Symbol HACL1 contributors: np - updated : 19-01-2005
HGNC name 2-hydroxyacyl-CoA lyase 1
HGNC id 17856
Location 3p25.1      Physical location : 15.602.241 - 15.643.130
Synonym name
  • 2-hydroxyphytanoyl-CoA lyase
  • phytanoyl-CoA 2-hydroxylase 2
  • Synonym symbol(s) HPCL2, 2-HPCL, HPCL, HSPC279, PHYH2
    EC.number 4.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 41.00 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2037 63 578 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Hearing/Equilibriumearinner   
     earmiddle   
    Nervousbrain    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a thiamine pyrophosphate-binding consensus domain is present in the C-terminal part
  • HOMOLOGY
    Homologene
    FAMILY
  • TPP enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • catalyzing the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • one thiamine pyrophosphate and 1 magnesium ion per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS