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FLASH GENE
Symbol NTM contributors: mct - updated : 23-06-2020
HGNC name neurotrimin
HGNC id 17941
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal sequence
  • three Ig-like domains
  • six cysteines that likely form intradomain disulfide bonds
  • a C-terminal GPI attachment site
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ntm
    Homologene
    FAMILY
  • immunoglobulin C-2 type family
  • plasticity-associated IgLON family neural adhesion molecules
  • IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules
    • CATEGORY adhesion , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be promoting neurite outgrowth and adhesion via a homophilic mechanism
  • LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
  • IgLON cell adhesion molecules (CAMs) participate in regulating synapse formation in hippocampal neurons
  • role for all IgLON family members in promoting neurite extension from cortical neurons
  • NTM exerts an inhibitory impact on neurite outgrowth
  • NTM is linked to intelligence and cognitive function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role for neurotrimin in mediating estrogen-induced sympathetic pruning in some peripheral targets
  • interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
  • IgLONs maintain an extended conformation and that their dimerization occurs through the first Ig domain of each monomer and is Ca2+ independent
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased selectively in the myometrium during the high-estrogen phase of the estrous cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • NTM is a novel biomarker in heart failure
    • Therapy target
    ANIMAL & CELL MODELS