Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

NTM

contributors: mct - updated : 23-06-2020

HGNC name	neurotrimin
HGNC id	17941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex     Homo sapiens   brain hindbrain pons   highly Homo sapiens   brain hindbrain cerebellum       spinal cord       highly Homo sapiens Olfactory (smell) olfactory bulb         Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous Purkinje cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal sequence
	three Ig-like domains
	six cysteines that likely form intradomain disulfide bonds
	a C-terminal GPI attachment site

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Ntm

Homologene

FAMILY	immunoglobulin C-2 type family
	plasticity-associated IgLON family neural adhesion molecules
	IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules

CATEGORY

adhesion , immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be promoting neurite outgrowth and adhesion via a homophilic mechanism
	LSAMP and NTM promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions
	IgLON cell adhesion molecules (CAMs) participate in regulating synapse formation in hippocampal neurons
	role for all IgLON family members in promoting neurite extension from cortical neurons
	NTM exerts an inhibitory impact on neurite outgrowth
	NTM is linked to intelligence and cognitive function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	role for neurotrimin in mediating estrogen-induced sympathetic pruning in some peripheral targets
	interplay between LSAMP and NTM in regulating tissue homeostasis: the impact of NTM on cellular proliferation was dependent on LSAMP, and LSAMP appeared to be a positive regulator of apoptosis in the presence of NTM
	IgLONs maintain an extended conformation and that their dimerization occurs through the first Ig domain of each monomer and is Ca2+ independent

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased selectively in the myometrium during the high-estrogen phase of the estrous cycle

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	NTM is a novel biomarker in heart failure
Therapy target

ANIMAL & CELL MODELS