Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MOGAT2 contributors: mct - updated : 11-01-2017
HGNC name monoacylglycerol O-acyltransferase 2
HGNC id 23248
Location 11q13.5      Physical location : 75.428.933 - 75.442.330
Synonym name acyl CoA:monoacylglycerol acyltransferase 2
Synonym symbol(s) DGAT2L5, FLJ22644, MGAT2, DGAT2L5., hDC5
EC.number 2.3.1.22
DNA
TYPE functioning gene
STRUCTURE 15.14 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2765 - 334 - 2014 25164810
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 intestinesmall intestine    Mus musculus
 liver     Homo sapiens
 stomach     Homo sapiens
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposewhite   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • catalyzing the synthesis of diacylglycerol, a precursor of triacylglycerol
  • playing a major role in the absorption of dietary fat in the intestine by catalyzing the resynthesis of triacylglycerol in enterocytes
  • in the intestine, plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes
  • is a key determinant of energy metabolism in response to dietary fat, suggesting that the inhibition of this enzyme may prove to be a useful strategy for treating obesity and other metabolic diseases associated with excessive fat intake
  • in the intestine plays an indispensable role in enhancing metabolic efficiency but also raise the possibility that MOGAT2 in other tissues may contribute to the regulation of energy metabolism
  • adult-onset MGAT2 deficiency mitigates metabolic disorders induced by high-fat feeding and MGAT2 modulates early postnatal nutrition and may program metabolism later in life
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DGAT2 interacted with monoacylglycerol acyltransferase MOGAT2, an enzyme that catalyzes the synthesis of diacylglycerol
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    blocking MOGAT activity in enterocytes is a feasible approach to inhibit fat absorption and treat obesity
    ANIMAL & CELL MODELS
  • mice lacking the gene MOGAT2, which codes for an MGAT highly expressed in the small intestine, are resistant to obesity and other metabolic disorders induced by high-fat feeding