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FLASH GENE
Symbol PSMG2 contributors: mct - updated : 06-11-2024
HGNC name proteasome (prosome, macropain) assembly chaperone 2
HGNC id 24929
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N-glycosylation sites
  • three N-myristoylation sites
  • several phosphorylation sites
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Tnfsf5ip1
    ortholog to rattus Tnfsf5ip1_predicted
    ortholog to chicken TNFSF5IP1
    Homologene
    FAMILY
  • PSMG2 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in the maturation of 20S proteasomes
  • is a proteaseome assembly chaperone that dimerizes with PSMG1, to form the PSMG1/PSMG2 complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer PSMG1 and PSMG2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic mutant TARDBP interacts with proteasome assembly proteins PSMG2, which might lead to the impairment of the proteasomal activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PRAAS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS