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FLASH GENE

Symbol

PSMG2

contributors: mct - updated : 06-11-2024

HGNC name	proteasome (prosome, macropain) assembly chaperone 2
HGNC id	24929

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020232 7 - 1070 NP_064617 - 264 - 2006 17189198 NM_147163 7 - 983 NP_671692 - 233 - 2006 17189198

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix   moderately   male system testis     moderately Urinary bladder       predominantly   kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-glycosylation sites
	three N-myristoylation sites
	several phosphorylation sites

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to murine Tnfsf5ip1
	ortholog to rattus Tnfsf5ip1_predicted
	ortholog to chicken TNFSF5IP1

Homologene

FAMILY

PSMG2 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	involved in the maturation of 20S proteasomes
	is a proteaseome assembly chaperone that dimerizes with PSMG1, to form the PSMG1/PSMG2 complex

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heterodimer PSMG1 and PSMG2

INTERACTION

DNA

RNA

small molecule

protein

cytoplasmic mutant TARDBP interacts with proteasome assembly proteins PSMG2, which might lead to the impairment of the proteasomal activity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PRAAS4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS