Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZC4H2 contributors: mct - updated : 13-01-2022
HGNC name zinc finger, C4H2 domain containing
HGNC id 24931
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C4H2-type zinc finger
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localized to the postsynaptic compartment of excitatory synapses
  • basic FUNCTION
  • should have a neuronal function during fetal growth
  • plays an important role during embryonic development of the central and peripheral nervous systems
  • RNF220 and its cofactor ZC4H2 participate in ventral neural tube patterning by modulating Shh/Gli signaling
  • ubiquitin E3 ligase RNF220 and its co-factor ZC4H2 are required for multiple neural developmental processes through different targets, including spinal cord patterning and the development of the cerebellum and the locus coeruleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • RNF220 cooperates with ZC4H2 to specify spinal progenitor domains (
  • ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling
  • ZC4H2 is a positive modulator of TRPV4
  • ZC4H2 and RNF220 are likely involved in the regulation of neural stem cell proliferation and differentiation through CEND1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WRWF , AGMCX2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS