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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ZC4H2

contributors: mct - updated : 13-01-2022

HGNC name	zinc finger, C4H2 domain containing
HGNC id	24931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	AGMCX2 arthrogryposis multiplex congenita 2 WRWF Wieacker-Wolf syndrome
Location	Xq11.2      Physical location : 64.136.249 - 64.254.593
Synonym name	hepatocellular carcinoma-associated antigen 127
	KIAA1166
Synonym symbol(s)	HCA127, KIAA1166, MCS, MRXS4, WRWF, WRWFFR, WWS

DNA

TYPE	functioning gene
STRUCTURE	118.94 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018684 5 - 2189 NP_061154 - 224 - 2013 23623388 NM_001243804 5 - 2719 NP_001230733 - 201 - 2013 23623388 NM_001178032 5 - 2974 NP_001171503 - 201 - 2013 23623388 NM_001178033 4 - 2649 NP_001171504 - 176 - 2013 23623388

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly Mus musculus   brain basal nuclei       Homo sapiens Reproductive female system uterus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining neuroepithelium

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C4H2-type zinc finger

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	localized to the postsynaptic compartment of excitatory synapses

basic FUNCTION	should have a neuronal function during fetal growth
	plays an important role during embryonic development of the central and peripheral nervous systems
	RNF220 and its cofactor ZC4H2 participate in ventral neural tube patterning by modulating Shh/Gli signaling
	ubiquitin E3 ligase RNF220 and its co-factor ZC4H2 are required for multiple neural developmental processes through different targets, including spinal cord patterning and the development of the cerebellum and the locus coeruleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	RNF220 cooperates with ZC4H2 to specify spinal progenitor domains (
	ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling
	ZC4H2 is a positive modulator of TRPV4
	ZC4H2 and RNF220 are likely involved in the regulation of neural stem cell proliferation and differentiation through CEND1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

WRWF , AGMCX2

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS