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FLASH GENE
Symbol DVL1L1 contributors: - updated : 05-09-2007
HGNC name dishevelled, dsh homolog 1 (Drosophila)-like 1
HGNC id 3085
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Cardiovascularheart    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text several tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Dlg, Discs-large suppressor tumor protein (DHR/GLGZ/PDZ) motif
  • PDZ domain may play an essential role in both pathways, and binds directly to Frizzled receptors
    • HOMOLOGY
    interspecies homolog to Drosophila dishevelled segment polarity-like gene
    homolog to C.elegans t05c12.6a
    Homologene
    FAMILY DSH family
    CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • transduces WNT signals from the receptor Frizzled (Fz) to downstream components in canonical and noncanonical WNT signaling pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Wnt signaling pathways involved in embryo development as well as in tumorigenesis
    a component key component of the WNT signaling and planar polarity pathways
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with nucleoredoxin (NRX), a thioredoxin (TRX) family protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in the Di George syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS