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FLASH GENE

Symbol

HAPLN4

contributors: - updated : 05-07-2005

HGNC name	hyaluronan and proteoglycan link protein 4
HGNC id	31357

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one immunoglobulin-like V-type domain
	two link domains

HOMOLOGY

Homologene

FAMILY

HAPLN family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	stabilizing the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix
	involved in the formation of extracellular matrix contributing to perineuronal nets and facilitating the understanding of a functional role of these extracellular matrices

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

colocalizing with BCAN in perineuronal nets

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS