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FLASH GENE

Symbol

C12orf57

contributors: mct - updated : 03-04-2013

HGNC name	chromosome 12 open reading frame 57
HGNC id	29521

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease
Location	12p13.31      Physical location : 7.053.202 - 7.055.164
Synonym name	likely ortholog of mouse gene rich cluster, C10 gene
Synonym symbol(s)	GRCC10, C10, FLJ17308

DNA

TYPE	functioning gene
STRUCTURE	1.96 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138425 3 - 574 NP_612434 13 126 - -

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Mus musculus Adult Nervous brain         Mus musculus Adult   brain hindbrain cerebellum   highly Homo sapiens Adult   brain         Homo sapiens Fetal Reproductive male system testis     moderately Homo sapiens Adult Respiratory lung       highly Mus musculus Adult   lung       highly Homo sapiens Adult Urinary kidney         Mus musculus Adult Visual eye         Mus musculus Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Membrane serous membrane pericardium     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine C10

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	potentially required for development of the human corpus callosum
	must be playing an important developmental role in both the brain and eye, although the exact role remains unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CLBM3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS