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FLASH GENE
Symbol GMPPB contributors: mct - updated : 14-09-2013
HGNC name GDP-mannose pyrophosphorylase B
HGNC id 22932
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to GMPPA
Homologene
FAMILY transferase hexapeptide repeat family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,cytosolic
text
  • localizes to the cytosol, in agreement with its role in cytosolic synthesis of nucleotide sugars
    • basic FUNCTION
  • catalyzing the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides
  • may be involved in the regulation of cell cycle progression
  • catalyzes the formation of GDP-mannose from mannose-1-phosphate and GTP, and is required in four glycosylation pathways
    • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component beta subunit of GMPP heterodimerizing with an alpha subunit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MDDGC14 , MDDGB14 , MDDGA14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS