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FLASH GENE

Symbol

GMPPB

contributors: mct - updated : 14-09-2013

HGNC name	GDP-mannose pyrophosphorylase B
HGNC id	22932

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013334 8 - 1688 NP_037466 - 387 - 2000 11082198 GMPPb I1 NM_021971 9 - 1607 NP_068806 - 360 - 2000 11082198 GMPPB I2

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to GMPPA

Homologene

FAMILY

transferase hexapeptide repeat family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
text	localizes to the cytosol, in agreement with its role in cytosolic synthesis of nucleotide sugars

basic FUNCTION	catalyzing the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides
	may be involved in the regulation of cell cycle progression
	catalyzes the formation of GDP-mannose from mannose-1-phosphate and GTP, and is required in four glycosylation pathways

CELLULAR PROCESS	cell cycle, progression

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

beta subunit of GMPP heterodimerizing with an alpha subunit

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MDDGC14 , MDDGB14 , MDDGA14

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS