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FLASH GENE
Symbol TMX2 contributors: mct/npt - updated : 11-12-2019
HGNC name thioredoxin-related transmembrane protein 2
HGNC id 30739
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide
  • a potential transmembrane domain
  • one Trx-like domain with an unusual catalytic motif, SNDC instead of CXXC, and is therefore thought to be inactive in terms of oxidoreductase activity (Sugiura 2010)
  • an Myb DNA-binding domain repeat signature
  • an ER-targeting signal sequence,
  • an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif)
  • a dileucine motif in the tail
    • HOMOLOGY
    interspecies homolog to rattus Tmx2
    Homologene
    FAMILY
  • thioredoxin superfamily, thioredoxin family protein
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    intracellular,nuclear envelope,ext
    text
  • localizes to the ER mitochondria-associated membranes (MAMs)
  • TMX2 localizes in the outer nuclear membrane with its N-terminus and C-terminus facing the cytoplasm
    • basic FUNCTION
  • thought to be redox-inactive (Sugiura 2010)
  • TMX2 works as a regulator of protein nuclear transport, and TMX2 facilitates the nucleocytoplasmic RAN cycle by interaction with nuclear pore proteins
  • is a sensor in the mitochondria-associated membranes (MAMs)-regulated redox signaling pathway
  • key molecule in the ER-mitochondrial redox regulation of brain development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PMGMS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS