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FLASH GENE

Symbol

SH3BGR

contributors: - updated : 29-04-2004

HGNC name	SH3 domain binding glutamic acid-rich protein
HGNC id	10822

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas       highly Nervous brain         Reproductive male system prostate     highly Respiratory lung         Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a proline-rich region containing the consensus sequence of a SH3 domain
	a carboxy-terminal glutamic acid rich region,putatively assuming a coiled-coil structure

HOMOLOGY

interspecies	homolog to murine Sh3brg
	homolog to C.elegans ZK856.10
	homolog to C.elegans R05F9.10

Homologene

FAMILY

SH3BRG family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus

basic FUNCTION

SH3/SH2 adaptor protein,involved in protein complex assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

maybe a part of a multimeric complex (Scartezzini,97)

INTERACTION

DNA

RNA

small molecule

protein

SH3 domain binding

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS