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FLASH GENE
Symbol FMN2 contributors: mct - updated : 01-03-2014
HGNC name formin 2
HGNC id 14074
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus of FMN2 is the important domain required for CDKN1A stability
  • a FH1 domain containing 11 proline repeats
  • a short sequence motif C-terminal adjacent to the formin-2-FH2 domain could be characterized that mediates the interaction with SPIRE1 and is conserved among the members of the Fmn subgroup of formins
    • HOMOLOGY
    interspecies homolog to murine Fmn2
    Homologene
    FAMILY formin homology family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleolus
    text
  • localizes to punctae along dendrites
    • basic FUNCTION
  • play a role in cytoskeletal organization and/or establishment of cell polarity
  • may be involved in maintenance of the meiotic spindle
  • is involved in the formation of a dynamic actin meshwork on meiotic spindle and the migration of chromosomes
  • SPIRE1, SPIRE2 cooperate with FMN2 to drive asymmetric oocyte division
  • is a crucial protein involved in the control of CDKN1A (
  • has an important role in cytoskeletal organization and actin nucleation
  • in mammalian oocytes, three actin binding proteins, FMN2, SPIRE1, and profilin, synergistically organize a dynamic cytoplasmic actin meshwork that mediates translocation of the spindle toward the cortex and is required for successful fertilization
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPIRE1 and SPIRE2 cooperate with Formin-2 (FMN2) to nucleate actin filaments
  • target regulated by induction of CDKN1A and by multiple other stress responses, including DNA damage and hypoxia, which have in common activation of cell cycle arrest
  • SPIRE1 recruits FMN2 and facilitates its association with barbed ends, followed by rapid processive assembly and release of SPIRE1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NSMR9
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma
    constitutional   deletion    
    in a boy with non-syndromic intellectual disability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • germline inactivation of mouse Fmn2 resulted in animals with decreased spine density that have a conditioned fear-learning defect