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FLASH GENE
Symbol RINT1 contributors: mct/npt - updated : 28-08-2019
HGNC name RAD50 interactor 1
HGNC id 21876
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil domain within its N-terminal 150 amino acids,
  • a conserved central domain of about 350 amino acids,
  • a C-terminal region of 90 amino acids
    • HOMOLOGY
    interspecies homolog to yeast Tip20
    Homologene
    FAMILY
  • RINT1 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text localized at the Golgi apparatus and the centrosome in addition to the endoplasmic reticulum (Lin 2007)
    basic FUNCTION
  • may play a role in the regulation of cell cycle control after DNA damage
  • serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division (Lin 2007)
  • essential for telomere length control (Kong 2006)
  • Rad50-interacting protein that participates in radiation-induced G2/M checkpoint control (Arasaki 2007)
  • coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18 (Arasaki 2007)
  • is also required for endosome-to-trans-Golgi network trafficking
  • crucial roles of RINT1 in genomic stability maintenance, as well as in prevention of ER stress and autophagy
  • new role of RINT1 in coordination with the COG complex
  • RAD50-interacting protein and its function was therefore linked to the maintenance of genomic stability
  • involvement of RINT1 in the regulation of neuronal autophagy
  • RINT1 was implicated in the cell cycle checkpoint, membrane trafficking, Golgi apparatus and centrosome dynamic integrity, and telomere length control
  • role for MCRS1 and RINT1 in cancer development
  • influences cellular homeostasis through maintenance
    • of endoplasmic reticulum, Golgi and centrosome integrity and regulation of vesicle transport, autophagy and the G2/M checkpoint
  • RINT1 and NBAS, as part of the NRZ complex, do play a role in docking and fusion of transport vesicles in the trans-Golgi network as a component of an endoplasmic reticulum (ER) tethering complex which binds target SNAREs at the ER
    • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RAD50
  • interacting with RBL2
  • together with the dynamitin-interacting protein ZW10 and others, is associated with syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE involved in membrane trafficking between the ER and Golgi (Arasaki 2007)
  • NBAS links between USE1 and ZW10-RINT1 and is involved in Golgi-to-ER transport
  • mediates the association of ZW10 (mammalian Dsl1) with endoplasmic reticulum-localized SNARE proteins
  • MCRS1 directly interacts with RINT1
  • RINT1 interacts with NBAS, recently implicated in recurrent acute liver failure (RALF), and UVRAG, to facilitate Golgi-to-ER retrograde vesicle transport
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALFSA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation   --over  
    as well as the presence of somatic missense mutations in RINT1 were associated with colorectal cancer development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas
    • Therapy target
    ANIMAL & CELL MODELS