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FLASH GENE
Symbol TNFAIP8 contributors: mct - updated : 15-09-2010
HGNC name tumor necrosis factor, alpha-induced protein 8
HGNC id 17260
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • oncogenic factor in cancer cells and negative mediator of apoptosis in certain cell types
  • Galpha(i)-TNFAIP8-mediated rescue of pre-oncogenic cells can may be enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation
  • contributes to the regulation of renal functions
  • crucial in regulating glucocorticoid-mediated apoptosis of thymocytes
  • one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury
    • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component novel NR2FI complex with TNFAIP8 that functions as a repressor of transcription and may play a role in the TNFalpha signaling pathways
    INTERACTION
    DNA
    RNA
    small molecule
    protein preferentially interacted with activated Galpha(i) proteins, consistent with direct Galpha(i)-TNFAIP8 couplin
    cell & other
    REGULATION
    induced by the activation of the transcription factor NF-kappaB
    repressed by NR2F1 (repressed by NR2FI in a manner that required several of the component proteins of the NR2FI complex)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS