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FLASH GENE

Symbol

TNFAIP8

contributors: mct - updated : 15-09-2010

HGNC name	tumor necrosis factor, alpha-induced protein 8
HGNC id	17260

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q23.1      Physical location : 118.604.417 - 118.730.293
Synonym name	head and neck tumor and metastasis-related protein
	NF-kappa-B-inducible DED-containing protein
	TNF-induced protein GG2-1
Synonym symbol(s)	GG2-1, SCC-S2, MDC-3.13, NDED, SCCS2

DNA

TYPE	functioning gene
STRUCTURE	125.88 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014350 2 - 2015 NP_055165 23 198 - PMID: 10644768 NM_001077654 2 - 1979 NP_001071122 21.9 188 - PMID: 10644768

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine ileum     Reproductive female system uterus       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Epithelial absorptive excretory digestive epithelium (mucosa)

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	oncogenic factor in cancer cells and negative mediator of apoptosis in certain cell types
	Galpha(i)-TNFAIP8-mediated rescue of pre-oncogenic cells can may be enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation
	contributes to the regulation of renal functions
	crucial in regulating glucocorticoid-mediated apoptosis of thymocytes
	one of critical components of a signal transduction pathway that links mesangial cell proliferation to diabetic renal injury

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

novel NR2FI complex with TNFAIP8 that functions as a repressor of transcription and may play a role in the TNFalpha signaling pathways

INTERACTION

DNA

RNA

small molecule

protein

preferentially interacted with activated Galpha(i) proteins, consistent with direct Galpha(i)-TNFAIP8 couplin

cell & other

REGULATION

induced by

the activation of the transcription factor NF-kappaB

repressed by

NR2F1 (repressed by NR2FI in a manner that required several of the component proteins of the NR2FI complex)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS