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FLASH GENE
Symbol GGN contributors: mct - updated : 29-06-2022
HGNC name gametogenetin
HGNC id 18869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Ggn (74.9 pc)
homolog to murine Ggn (75.3 pc)
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleolus
intracellular,nuclear envelope
text during mid-prophase, redistributes from a solely cytoplasmic localization to both cytoplasmic and nuclear in late prophase spermatocytes and round spermatids, and ultimately incorporated into the sperm tail
basic FUNCTION
  • regulating the localization of FANCL
  • playing a role in spermatogenesis
  • potential role for the GGN-CRISP2 complex in sperm tail development and/or motility
  • GGN plays likely a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos
  • played a tumor-promoting role in bladder cancer through regulation of NFKB1/caspase3-mediated apoptosis signaling
  • potential oncogenic role for GGN in Colorectal cancer (CRC) progress
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS reproduction/sex
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FANCL, GGNBP1 and ZNF403/GGNBP2
  • interacting with CRISP2, between the ion channel regulatory region within the CRISP2 CRISP domain and the carboxyl-most 158 AAs of GGN
  • GGN is a testis-enriched protein that has been shown to bind to the DNA repair protein FANCL
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF69
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder cancer tissues compared to the control and was associated with the unsatisfactory survival rate of patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might serve as a biomarker, for CRC
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    therapeutic target for Colorectal cancer
    ANIMAL & CELL MODELS
  • pachytene spermatocytes of the Ggn heterozygous knockout mice showed an increased incidence of unrepaired DNA double strand breaks (DSBs)