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FLASH GENE

Symbol

GGN

contributors: mct - updated : 29-06-2022

HGNC name	gametogenetin
HGNC id	18869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.68 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152657 4 - 2168 NP_689870 66.6 652 - 2003 12574169

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary ovarian follicle     Homo sapiens   male system testis     specific

cells

System Cell Pubmed Species Stage Rna symbol Reproductive granulosa cell Homo sapiens Reproductive spermatid Homo sapiens Reproductive spermatocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Ggn (74.9 pc)
	homolog to murine Ggn (75.3 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleolus
	intracellular,nuclear envelope
text	during mid-prophase, redistributes from a solely cytoplasmic localization to both cytoplasmic and nuclear in late prophase spermatocytes and round spermatids, and ultimately incorporated into the sperm tail

basic FUNCTION	regulating the localization of FANCL
	playing a role in spermatogenesis
	potential role for the GGN-CRISP2 complex in sperm tail development and/or motility
	GGN plays likely a role in male meiotic DSB repair and is absolutely required for the survival of pre-implantation embryos
	played a tumor-promoting role in bladder cancer through regulation of NFKB1/caspase3-mediated apoptosis signaling
	potential oncogenic role for GGN in Colorectal cancer (CRC) progress

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

reproduction/sex

text	spermatogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with FANCL, GGNBP1 and ZNF403/GGNBP2
	interacting with CRISP2, between the ion channel regulatory region within the CRISP2 CRISP domain and the carboxyl-most 158 AAs of GGN
	GGN is a testis-enriched protein that has been shown to bind to the DNA repair protein FANCL

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF69

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in bladder cancer tissues compared to the control and was associated with the unsatisfactory survival rate of patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	might serve as a biomarker, for CRC
Therapy target
	System Type Disorder Pubmed cancer digestive colon therapeutic target for Colorectal cancer

ANIMAL & CELL MODELS

pachytene spermatocytes of the Ggn heterozygous knockout mice showed an increased incidence of unrepaired DNA double strand breaks (DSBs)