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FLASH GENE
Symbol HOOK1 contributors: mct - updated : 31-03-2015
HGNC name hook homolog 1 (Drosophila)
HGNC id 19884
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal domain,
  • a large and central coiled-coil domain mediating the homodimerization
  • a C-terminal domain
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Hook1 (92.7 pc)
    homolog to murine Hook1 (92.6 pc)
    intraspecies homolog to HOOK2 and HOOK3
    Homologene
    FAMILY
  • hook family
  • vdp/uso1/ybl047c family
    • CATEGORY regulatory , structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • required for protein transport from the ER to the golgi complex
  • involved in tethering membrane bound organelles to the cytoskeleton
  • required for spermatid differentiation
  • probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton
  • microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into RAB22A-dependent tubules associated with recycling
  • role for HOOK1 as an endosomal cargo adaptor that routes Clathrin-independent endocytosis (CIE) cargo to the recycling endosomes
  • HOOK1, microtubules, and RAB22A work in coordination to directly recycle the cargo and facilitate cell spreading
    • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • spermatogenesis
  • microtubule cytoskeleton organization
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CLN3
  • interacting with microtubules
  • interacting with VPS18
  • HOOK1 was an endogenous negative regulator of PTPN11 phosphatase activity
  • CCDC81 seems to interact directly with microtubules and localizes to the microtubular manchette of elongating spermatids, resembling the previously reported localization of HOOK1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS