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FLASH GENE
Symbol HOOK1 contributors: mct - updated : 31-03-2015
HGNC name hook homolog 1 (Drosophila)
HGNC id 19884
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinerectum  
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Reproductivefemale systemuteruscervix moderately
 male systemtestis  highly
Urinarykidney    
Visualeyeanterior segmentcornea  
 eyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal domain,
  • a large and central coiled-coil domain mediating the homodimerization
  • a C-terminal domain
    • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Hook1 (92.7 pc)
    homolog to murine Hook1 (92.6 pc)
    intraspecies homolog to HOOK2 and HOOK3
    Homologene
    FAMILY
  • hook family
  • vdp/uso1/ybl047c family
    • CATEGORY regulatory , structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • required for protein transport from the ER to the golgi complex
  • involved in tethering membrane bound organelles to the cytoskeleton
  • required for spermatid differentiation
  • probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton
  • microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into RAB22A-dependent tubules associated with recycling
  • role for HOOK1 as an endosomal cargo adaptor that routes Clathrin-independent endocytosis (CIE) cargo to the recycling endosomes
  • HOOK1, microtubules, and RAB22A work in coordination to directly recycle the cargo and facilitate cell spreading
    • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • spermatogenesis
  • microtubule cytoskeleton organization
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CLN3
  • interacting with microtubules
  • interacting with VPS18
  • HOOK1 was an endogenous negative regulator of PTPN11 phosphatase activity
  • CCDC81 seems to interact directly with microtubules and localizes to the microtubular manchette of elongating spermatids, resembling the previously reported localization of HOOK1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS