basic FUNCTION
| required for protein transport from the ER to the golgi complex |
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involved in tethering membrane bound organelles to the cytoskeleton |
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required for spermatid differentiation |
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probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton |
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microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 into RAB22A-dependent tubules associated with recycling |
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role for HOOK1 as an endosomal cargo adaptor that routes Clathrin-independent endocytosis (CIE) cargo to the recycling endosomes |
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HOOK1, microtubules, and RAB22A work in coordination to directly recycle the cargo and facilitate cell spreading |