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FLASH GENE
Symbol SCUBE2 contributors: mct/pgu - updated : 24-09-2009
HGNC name signal peptide, CUB domain, EGF-like 2
HGNC id 30425
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five recognizable motifs: an N-terminal signal peptide sequence
  • nine(EGF)-like repeats, that could mediate cell-cell homophilic adhesions in a calcium-dependent fashion, interact with CDH1 (a master tumor suppressor), and decrease the CTNNB signaling pathway
  • a spacer region
  • three cysteine-rich repeats
  • and one CUB domain at the C-terminus, antagonizing autocrine BMP-mediated signaling
    • conjugated GlycoP
    mono polymer homomer , heteromer , octamer
    HOMOLOGY
    interspecies homolog to murine Scube2 (89.4pc)
    homolog to rattus Scube2 (89.5pc)
    Homologene
    FAMILY
  • SCUBE family
    • CATEGORY tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play important roles in development, inflammation, and thrombosis
  • positive component of the hedge hog signal, acting upstream of ligand binding at the plasma membrane
  • has growth inhibitory effects through a coordinated regulation of two distinct mechanisms: antagonizing bone morphogenetic protein and suppressing the CTNNB pathway in breast cancer cells
  • can act as a novel breast tumor suppressor gene
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , inflammation
    PATHWAY
    metabolism
    signaling
    a component
  • forming homo-oligomers or hetero-oligomers with SCUBE1 or SCUBE3
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Ca2+
    • protein
  • interacting with SHH and its receptor PTCH1, enhancing the SHH signaling activity within the cholesterol-rich raft microdomains of the plasma membrane
  • interacts and co-localizes with CDH1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    silenced or inactivated by similar regulatory mechanisms during breast cancer progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • suppressing breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer
    • Marker
    Therapy target
    ANIMAL & CELL MODELS