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FLASH GENE
Symbol EXOSC3 contributors: mct - updated : 11-05-2017
HGNC name exosome component 3
HGNC id 17944
Corresponding disease
PCH1B pontocerebellar hypoplasia, type 1B
SPG84 spastic paraplegia 84
Location 9p13.2      Physical location : 37.780.307 - 37.785.067
Synonym name
  • CGI-102 protein
  • exosome component Rrp40
  • ribosomal RNA-processing protein 40
    • Synonym symbol(s) p10, RRP40, Rrp40p, CGI-102
    DNA
    TYPE functioning gene
    STRUCTURE 5.38 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1705 - 164 - 2002 11782436
    4 - 1857 - 275 - 2002 11782436
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast Rrp40
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • component of the exosome 3'->5' exoribonuclease complex, required for the 3'processing of the 7s pre-RNA to the mature 5.8s rRNA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH1B , SPG84
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS