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FLASH GENE

Symbol

ECRG4

contributors: mct/npt - updated : 10-03-2010

HGNC name	chromosome 2 open reading frame 40
HGNC id	24642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by CpG island hypermethylation in esophageal squamous cell carcinoma (Yue 2003) constitutional     --low   during chondrocyte dedifferentiation and cartilage destruction (Huh 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	candidate tumor suppressor gene in ESCC (esophageal squamous cell carcinoma), and is a candidate prognostic marker for ESCC (Li 2009)
	marker of differentiated articular chondrocyte and cartilage destruction, with a capacity to inhibit proliferation of differentiated chondrocytes (Huh 2009)
Marker
Therapy target

ANIMAL & CELL MODELS