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FLASH GENE
Symbol ECRG4 contributors: mct/npt - updated : 10-03-2010
HGNC name chromosome 2 open reading frame 40
HGNC id 24642
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies ortholog to murine 1500015O10Rik
Homologene
FAMILY
  • augurin family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text secreted protein that undergoes cleavage after secretion (Huh 2009)
    basic FUNCTION
  • may be involved in the carcinogenesis of esophageal cancer
  • silenced via promoter hypermethylation in different types of cancer and may act as inhibitor of cell proliferation in colorectal carcinoma cells, playing a role as extracellular signaling molecule (Gotze 2009)
  • having function as a marker of differentiated articular chondrocytes and cartilage destruction (Huh 2009)
  • marker of differentiated articular chondrocyte and cartilage destruction, with a capacity to inhibit proliferation of differentiated chondrocytes (Huh 2009)
  • chondrocyte-specific gene involved in cartilage development and destruction (Huh 2009)
  • plays a role in catabolic regulation by ECM reorganization or affects synovial fluids in joint cartilage or adjacent tissues, such as bone and synovial tissue (Huh 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by CpG island hypermethylation in esophageal squamous cell carcinoma (Yue 2003)
    constitutional     --low  
    during chondrocyte dedifferentiation and cartilage destruction (Huh 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate tumor suppressor gene in ESCC (esophageal squamous cell carcinoma), and is a candidate prognostic marker for ESCC (Li 2009)
  • marker of differentiated articular chondrocyte and cartilage destruction, with a capacity to inhibit proliferation of differentiated chondrocytes (Huh 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS