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FLASH GENE
Symbol ECRG4 contributors: mct/npt - updated : 10-03-2010
HGNC name chromosome 2 open reading frame 40
HGNC id 24642
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Skeletonappendicular skeletonjointsynovia  
Visualeyeanterior segmentiris  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  highly
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • eye, anterior segment
  • expression in proliferating chondrocytes but not hypertrophic chondrocytes in the developing cartilage (Huh 2009)
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies ortholog to murine 1500015O10Rik
    Homologene
    FAMILY
  • augurin family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text secreted protein that undergoes cleavage after secretion (Huh 2009)
    basic FUNCTION
  • may be involved in the carcinogenesis of esophageal cancer
  • silenced via promoter hypermethylation in different types of cancer and may act as inhibitor of cell proliferation in colorectal carcinoma cells, playing a role as extracellular signaling molecule (Gotze 2009)
  • having function as a marker of differentiated articular chondrocytes and cartilage destruction (Huh 2009)
  • marker of differentiated articular chondrocyte and cartilage destruction, with a capacity to inhibit proliferation of differentiated chondrocytes (Huh 2009)
  • chondrocyte-specific gene involved in cartilage development and destruction (Huh 2009)
  • plays a role in catabolic regulation by ECM reorganization or affects synovial fluids in joint cartilage or adjacent tissues, such as bone and synovial tissue (Huh 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by CpG island hypermethylation in esophageal squamous cell carcinoma (Yue 2003)
    constitutional     --low  
    during chondrocyte dedifferentiation and cartilage destruction (Huh 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate tumor suppressor gene in ESCC (esophageal squamous cell carcinoma), and is a candidate prognostic marker for ESCC (Li 2009)
  • marker of differentiated articular chondrocyte and cartilage destruction, with a capacity to inhibit proliferation of differentiated chondrocytes (Huh 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS