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FLASH GENE
Symbol CFHR4 contributors: npt - updated : 12-04-2005
HGNC name complement factor H-related 4
HGNC id 16979
Location 1q32      Physical location : 196.857.211 - 196.887.762
Synonym symbol(s) FHR4, FHR-4, CFHL4, RP4-608O15.2
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text clustered with CFHL3, CFHL2, CFHL1
STRUCTURE 143.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located closely linked to HF1 gene
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - 63 559 plasma, liver Jozsi
  • nine complement control protein (CCP) domains
  • - splicing 1315 - 331 - Skerka
    truncated variant encoding a secreted protein of five domains
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 19 amino acid signal peptide
  • four N-linked glycosylation sites
  • five short consensus repeats (SCRs)
  • five CCP (complement control protein) domains
  • conjugated LipoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • factor H protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    text secreted in plasma
    basic FUNCTION
  • lipid transporter activity
  • enhancing the cofactor activity of factor H in C3b inactivation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to C3b and C3d
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS