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FLASH GENE

Symbol

CFHR4

contributors: npt - updated : 12-04-2005

HGNC name	complement factor H-related 4
HGNC id	16979

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32      Physical location : 196.857.211 - 196.887.762
Synonym symbol(s)	FHR4, FHR-4, CFHL4, RP4-608O15.2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with CFHL3, CFHL2, CFHL1
STRUCTURE	143.00 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

closely linked to HF1 gene

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed FHR4A - splicing - 63 559 plasma, liver Jozsi nine complement control protein (CCP) domains FHR4B - splicing 1315 - 331 - Skerka truncated variant encoding a secreted protein of five domains

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 19 amino acid signal peptide
	four N-linked glycosylation sites
	five short consensus repeats (SCRs)
	five CCP (complement control protein) domains

conjugated

LipoP

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

factor H protein family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
text	secreted in plasma

basic FUNCTION	lipid transporter activity
	enhancing the cofactor activity of factor H in C3b inactivation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to C3b and C3d

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS