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FLASH GENE
Symbol TCF15 contributors: npt/ - updated : 05-03-2008
HGNC name transcription factor 15 (basic helix-loop-helix)
HGNC id 11627
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (bHLH) protein
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Tcf15
    Homologene
    FAMILY
  • basic helix-loop-helix (BHLH) family of transcription factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functioning as an early transcriptional regulator
  • involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm (Quertermous 1994)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • mesoderm development
  • activator of transcription
    • PATHWAY
    metabolism
    signaling
    a component
  • efficient DNA binding required dimerization with another BHLH protein
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • ETV4 and ETV5, potentially through regulation of GBX2 and TCF15, are involved in the ES cell proliferation and induction of differentiation-associated genes in ES cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS