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FLASH GENE

Symbol

TCF15

contributors: npt/ - updated : 05-03-2008

HGNC name	transcription factor 15 (basic helix-loop-helix)
HGNC id	11627

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p13      Physical location : 584.638 - 590.910
Synonym name	bHLH-EC2 protein
	basic helix-loop-helix transcription factor 15
Synonym symbol(s)	EC2, PARAXIS, bHLHa40

DNA

TYPE	functioning gene
STRUCTURE	6.27 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TCF15 2 - 1227 21 199 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	pregnancy; early, in mesoderma and developing somites in the mouse

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic helix-loop-helix (bHLH) protein

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies

ortholog to murine Tcf15

Homologene

FAMILY

basic helix-loop-helix (BHLH) family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	functioning as an early transcriptional regulator
	involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm (Quertermous 1994)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	mesoderm development
	activator of transcription

PATHWAY

metabolism

signaling

a component

efficient DNA binding required dimerization with another BHLH protein

INTERACTION

DNA

binding

RNA

small molecule

protein

ETV4 and ETV5, potentially through regulation of GBX2 and TCF15, are involved in the ES cell proliferation and induction of differentiation-associated genes in ES cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS