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FLASH GENE
Symbol NELFB contributors: mct - updated : 01-04-2015
HGNC name negative elongation factor complex member B
HGNC id 24324
Location 9q34.3      Physical location : -
Synonym name
  • negative elongation factor protein B
  • cofactor of BRCA1
  • Synonym symbol(s) NELF-B, KIAA1182, DKFZP586B0519, COBRA1
    DNA
    TYPE functioning gene
    STRUCTURE 18.24 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2622 65 580 - 2003 12612062
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousnerve    
    Reproductivefemale systemuteruscervix  
     male systemprostate   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • NELF-B family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • negatively regulating the elongation of transcription
  • by RNA polymerase II
  • may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products
  • modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells
  • NELFB and BRCA1 may engage in common gene regulatory pathways to suppress breast cancer progression
  • important role of NELFA, NELFB in controlling RNA polymerase II (Pol II) pausing in transcription
  • helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes
  • NELFA and NELFB are each shown to act independently as competitive decelerators at two steps after the site of glucocorticoid receptor (GR) action and before or at the site of reporter gene activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • composed of 4 subunits : WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the first BRCT repeat of BRCA1
  • binds strongly to androgen receptor (AR) via its ligand-binding domain (LBD)
  • COBRA1 is required for NTRK3-induced apoptosis
  • in the absence of NTF3, the proteolytic cleavage of NTRK3 leads to the release of a killer fragment that triggers mitochondria-dependent apoptosis via the recruitment of COBRA1
  • BRCA1-interacting protein and subunit (with NELFA, -C/D, and -E) of the negative elongation factor (NELF) complex, which participates in RNA polymerase II pausing shortly after transcription initiation, especially for synchronized gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in metastatic and recurrent breast cancer, pointing to a tumor suppressor function in breast cancer development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS