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FLASH GENE
Symbol CIDEA contributors: mct - updated : 22-10-2011
HGNC name cell death-inducing DNA fragmentation factor alpha-like effector a
HGNC id 1976
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain is required for CIDEA-mediated development of enlarged lipid droplets
  • one CIDE-N domain
  • C-terminal domain directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation
    • HOMOLOGY
    interspecies homolog to murine Cidea
    Homologene
    FAMILY cell death-inducing DNA fragmentation factor-alpha-like effector family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocalizes around lipid droplets with perilipin, a regulator of lipolysis
  • localizes to both the cytoplasm and the nucleus in human white adipocytes
    • basic FUNCTION
  • activator of apoptosis
  • playing an important role in lipolysis regulation and metabolic complications of obesity, which is at least in part mediated by cross-talk between CIDEA and TNF-alpha
  • playing a role in adipose tissue energy expenditure
  • mitochondrial protein that negatively regulates the activity of the BAT uncoupling protein UCP1
  • Cide domain-containing proteins play an important role in sequestration of triglyceride within adipocytes, promoting whole-body insulin sensitivity
  • plays a central role in controlling metabolic flux in human adipose tissues through its regulation of fat storage in lipid droplets
  • playing a role in lipid-droplet structure or function
  • playing important roles in maintaining triglyceride stores in lean and obese individuals
  • involved in adipose tissue loss in cancer cachexia and this may, at least in part, be due to its ability to inactivate pyruvate dehydrogenase complex (
  • CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation (
  • CIDEA and CIDEC are closely involved in the progression of hepatic steatosis, and TIMP1 inhibits CIDEA gene expression through SREBF1 regulation
  • may prevent lipolysis by binding and shielding lipid droplets from lipase association
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to liver X receptors (NR1H2, NR1H3) and regulates their activity (could therefore be of importance for the regulation of metabolic processes in human adipose tissue)
    • cell & other
    REGULATION
    inhibited by by the DNA fragmentation factor DFF45
    DFFB
    repressed by CpG methylation of the promoter, regulating the Sp1/Sp3 binding sites
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased twofold in obese humans and normalized after weight reduction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential target for the treatment of obesity via the modulation of metabolic rate, based on the findings that CIDEA inhibits the brown adipose tissue uncoupling process
    ANIMAL & CELL MODELS