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FLASH GENE

Symbol

VAV1

contributors: mct - updated : 24-01-2015

HGNC name	vav 1 guanine nucleotide exchange factor
HGNC id	12657

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005428 27 - 2888 NP_005419 - 845 - 2000 10760587

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly

cell lineage	hematopoietic cell lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	tyrosine phosphorylation at the N-terminus plays a central role in regulating its activity
	a leucine zipper
	a helix-loop-helix (HLH)
	a calponin homology (CH)
	an atypical C1 domain, which possesses close structural homology to the typical C1 domains of protein kinase C but which fails to bind the second messenger diacylglycerol or the potent analogs, the phorbol esters
	a ZF domain
	a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
	a pleckstrin homology (PH)
	one SH2 domains
	intact C-terminal SH3 domain necessary for VAV1-induced transformation

HOMOLOGY

intraspecies

homolog to VAV proto-oncogene 1

Homologene

FAMILY

DBL family of GDP-GTP exchange factors, VAV family proto-oncogenes

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	GDP-GTP exchange factor (DBL homolog) for Rac or Rho(Arh) proteins (signal transduction)
	critical transducer of T cell receptor signals to the calcium, ERK and FNKB pathways
	functions in the hematopoietic system as a specific GDP/GTP nucleotide exchange factor regulated by tyrosine phosphorylation
	plays a central role in controlling central nervous system immune-mediated disease and proinflammatory cytokine production critical for disease pathogenesis
	essential signal transducer protein in the hematopoietic system, where it is expressed physiologically
	guanine nucleotide exchange factor activity is critical for the function of VAV1 as a transforming protein but not for NFAT stimulation
	its guanine nucleotide exchange activity is required for enhancing BCL2 promoter activity, and the VAV1 downstream substrate, small GTPase RAC2, was likely involved in the control of BCL2 expression
	hematopoietic cells that is indispensable for transducing the calcium-mobilizing signal
	VAV1 was originally described as a proto-oncogene of the hematopoietic lineage
	plays a critical role in hematologic cell signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	T cell and B cell development and activation

PATHWAY

metabolism

signaling

signal transduction

ERK and NFKB

a component

INTERACTION

DNA

RNA

small molecule

protein	co-interacting the activating effect of CD4/LCK in increase of BAX expression
	ZNF655
	important interaction with DNM2 that regulates actin reorganization and multiple signaling pathways in T lymphocytes
	KHDRBS1 is a VAV1 SH3C-associating protein
	interacting with IDO1 (inhibitory effects of IDO1 on T cell immune responses may be through downregulation of VAV1 protein expression and activation)
	association with other proteins, detected by SH2 profiling, might affect other VAV1-dependent activities, such as NFAT stimulation
	NCF2 binding to VAV1 involves their respective PB1 and ZF domains (PMID;
	interaction of VAV1 with PLCG1 (oncogenic truncation of VAV1 N-terminus elicits conformational changes that interfere with the VAV1-mediated activation of PLCG1 and inhibit calcium mobilization) (PMKID: 22474331)
	LIME is a transmembrane adaptor protein linking TCR stimulation to IS formation and integrin activation through activation of VAV1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS