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FLASH GENE

Symbol

ARHGAP27

contributors: - updated : 30-12-2005

HGNC name	Rho GTPase activating protein 27
HGNC id	31813

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an Src homology 3 (SH3) domain
	multiple WW domains, a proline-rich region
	a PH domain and a RhoGAP domain

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION

may be playing a role in clathrin-mediated endocytosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding protein for SH3KBP1 (its second SH3 domain binds to a proline-rich region of ARHGAP27)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS