Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DERL3 contributors: mct - updated : 20-08-2013
HGNC name Der1-like domain family, member 3
HGNC id 14236
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane segments
  • both the amino and carboxy termini in the cytosol
    • HOMOLOGY
    interspecies ortholog to yeast
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be specifically required for the degradation of misfolded proteins, associated with the ER
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DERL2 and DERL3 provide the missing link between EDEM1 and VCP in the process of degrading misfolded glycoproteins
  • SELK and SELS interact with the longer form of DERL3, Derlin-3b
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS