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FLASH GENE
Symbol DERL3 contributors: mct - updated : 20-08-2013
HGNC name Der1-like domain family, member 3
HGNC id 14236
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1085 - 239 - 2006 16449189
  • DERL3, isoform a
    • 7 - 3115 25 235 - 2006 16449189
    isoform b
    6 - 3216 - 205 - 2006 16449189
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Reproductivemale systemtestis   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • both the amino and carboxy termini in the cytosol
    • HOMOLOGY
    interspecies ortholog to yeast
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be specifically required for the degradation of misfolded proteins, associated with the ER
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DERL2 and DERL3 provide the missing link between EDEM1 and VCP in the process of degrading misfolded glycoproteins
  • SELK and SELS interact with the longer form of DERL3, Derlin-3b
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS