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FLASH GENE
Symbol TAAR1 contributors: mct - updated : 28-01-2012
HGNC name trace amine associated receptor 1
HGNC id 17734
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Tar1
homolog to murine Trar1
Homologene
FAMILY G-protein coupled receptor 1 family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • may be mediated by the G(s)-class of G-proteins which activate adenylate cyclase
  • regulator of dopaminergic neurotransmission
  • tonically activates inwardly rectifying K(+) channels, which reduces the basal firing frequency of dopamine (DA) neurons of the ventral tegmental area (VTA)
  • plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants
  • role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity
  • is potentially a negative modulator of monoaminergic neurotransmission
  • affects the dopaminergic system by regulating the firing rate of dopaminergic neurons or by altering DRD2 responsiveness to ligands
  • TAAR1 and DRD2 have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional interaction between TAAR1 and DRD2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    antipsychotic and anxiolytic potential of TAAR1 agonists
    ANIMAL & CELL MODELS
  • Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals