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FLASH GENE

Symbol

TAAR1

contributors: mct - updated : 28-01-2012

HGNC name	trace amine associated receptor 1
HGNC id	17734

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Rna function	expression of the mRNAs encoding these trace amine receptors in leukocytes
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     lowly   stomach       moderately Nervous brain diencephalon amygdala   lowly Homo sapiens Respiratory lung       lowly Urinary kidney       lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Tar1
	homolog to murine Trar1

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be mediated by the G(s)-class of G-proteins which activate adenylate cyclase
	regulator of dopaminergic neurotransmission
	tonically activates inwardly rectifying K(+) channels, which reduces the basal firing frequency of dopamine (DA) neurons of the ventral tegmental area (VTA)
	plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants
	role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity
	is potentially a negative modulator of monoaminergic neurotransmission
	affects the dopaminergic system by regulating the firing rate of dopaminergic neurons or by altering DRD2 responsiveness to ligands
	TAAR1 and DRD2 have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

functional interaction between TAAR1 and DRD2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed psychiatry     antipsychotic and anxiolytic potential of TAAR1 agonists

ANIMAL & CELL MODELS

Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals