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FLASH GENE

Symbol

SOX11

contributors: mct - updated : 23-01-2018

HGNC name	SRY (sex determining region Y)-box 11
HGNC id	11191

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.72 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter of non-malignant cells was consistently unmethylated whereas lymphoid neoplasms with silenced SOX11 tended to acquire DNA hypermethylation

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003108 1 - 8737 - 441 - 2006 17055661

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           mouth tongue       Nervous brain         Homo sapiens Adult Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	high levels in developing sensory neurons system, somites, limbs, facial mesenchyme, kidney, lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an high mobility group (HMG) domain
	a DNA binding domain responsible for selective cooperation with the POU factor POU3F2
	a autoinhibitory domain that can repress promiscuous binding of to DNA and plays an important role in regulating the recruitment of to specific genes
	a transactivation domain in the carboxyl terminus (transcription activation)

HOMOLOGY

interspecies	homolog to murine Sox11
	homolog to C.elegans Y56a3a.7

Homologene

FAMILY

SRY-related HMG box family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	modulator of LINE retroposons promoter activity
	playing a role in the developing nervous system
	playing a central regulatory role during neuronal maturation and mechanistically separate cell cycle withdrawal from the establishment of neuronal properties
	playing a central role in regulating events that promote neurite growth and neuron survival
	expression of SOX11 and POU3F3 may be modulated by the cell-type specific machinery
	required for neuron survive and neurite growth
	transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis
	pathogenic role of SOX11 is associated with its de novo expression in some aggressive lymphoid malignancies, which is mediated by a shift from inactivating to activating histone modifications
	SOX11 and SOX4 play critical roles in retinal development, during which they display specific and unique expression patterns
	contributes to tumor development by altering the terminal B-cell differentiation program of mantle cell lymphoma

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

metal binding,

protein	DBN1, SETMAR, HILPDA, are direct targets of the SOX11 protein (are direct transcriptional targets of the SOX11 protein)
	SOX11 represents a synergistic factor for WT1 in regulating the WNT4 gene expression that is critical for nephrogenesis during kidney ontogeny
	regulation of TANK expression is, at least in part, controlled by the injury-associated transcription factor SOX11
	PAX5 is one of the major SOX11 direct targets
	SOX11 is a potential regulator of GDF5 expression in joint maintenance, suggesting a possible role in the pathogenesis of osteoarthritis
	SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
	GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration

cell & other

REGULATION

induced by

retinoic acid for 5 weeks

ASSOCIATED DISORDERS

corresponding disease(s)

CSSS7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in classical medulloblastomas tumoral     --other   aberrantly expressed in mantle cell lymphoma (MCL)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS