Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

FUBP1

contributors: mct/pg - updated : 22-12-2020

HGNC name	far upstream element (FUSE) binding protein 1
HGNC id	4004

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human hepatocellular carcinoma (HCC) tumoral somatic mutation       CIC and FUBP1 mutations in oligodendrogliomas and in oligoastrocytomas tumoral       loss of function confers survival advantages to cells against metabolic stress and anti-cancer drugs tumoral     --over   in tongue squamous cell carcinoma (TSCC), correlated with TSCC cell proliferation and poor prognosis tumoral     --over   in clear cell renal cell carcinoma (ccRCC) tissues compared with adjacent noncancerous tissues tumoral     --over   in pancreatic cancer and associated with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	considered a novel biomarker for TSCC
	novel biomarker or an attractive treatment target of clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed cancer urinary   attractive treatment target of clear cell renal cell carcinoma (ccRCC) cancer digestive liver promote tumor-relevant functions by at least partly employing the microtubule-destabilizing factor stathmin and represent a new potential target structure for HCC treatment cancer endocrine pancreas Targeting FUBP1 may be a novel therapeutic strategy to overcome the immunotherapy resistance in pancreatic cancer

ANIMAL & CELL MODELS