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FLASH GENE

Symbol

FUBP1

contributors: mct/pg - updated : 22-12-2020

HGNC name	far upstream element (FUSE) binding protein 1
HGNC id	4004

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p31.1      Physical location : 78.413.592 - 78.444.777
Synonym name	DNA helicase V
	FUSE-binding protein 1
	epididymis secretory sperm binding protein
	far upstream element (FUSE) binding protein 1
Synonym symbol(s)	FBP, FUBP, FBP1, hDH V

DNA

TYPE	functioning gene
STRUCTURE	35.38 kb     20 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001376056 20 - 3626 NP_001362985 - 666 - 2019 30635626 NM_003902 20 - 2884 NP_003893 67.4 644 - 2019 30635626 NM_001376056 21 - 3626 NM_001376057 20 - 6711 NP_001362986 - 643 - 2019 30635626 NM_001376055 21 - 6774 NM_001303433 21 - 6777 NP_001290362 - 665 - 2019 30635626

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta       Reproductive female system uterus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Epithelial barrier lining endometrium     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four K-homology motifs (KH1-4) used for both nucleic acid binding and protein-protein association with PUF60
	C-terminal activation domain, which has physical contacts with TFIIH during the regulation

HOMOLOGY

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus
text	caspase-mediated cleavage leads to its decreased presence in the nucleus, concomitant with the marked downregulation of MYC and its various target proteins

basic FUNCTION	may be acting both as activator and repressor of transcription
	potential MYC regulator in renal, but not in prostate and bladder cancer
	activator of transcription of the proto-oncogene MYC
	important oncoprotein overexpressed in hepatocellular carcinoma that induces tumor propagation through direct or indirect repression of cell cycle inhibitors and proapoptotic target genes
	critical for cellular proliferation
	key regulator of cell growth and proliferation through its ability to selectively bind the NPM1 3prime UTR and repress NPM1 translation
	critical role for CIC and FUBP1 in the biology and pathology of oligodendrocytes
	FUBP1 and its recognition of single-stranded genomic DNA as an important element in the transcriptional regulation of hematopoietic stem cells (HSCs) self-renewal
	is a master regulator of transcription, translation, and RNA splicing
	essential functions in hematopoietic stem cell maintenance and survival
	FUBP1 promotes cell proliferation and survival, and it is overexpressed in a variety of cancers
	FUBP1 contributes to cell survival through supporting lactate-AkT1-MTOR axis
	may likely play both positive and negative roles in malignant development
	plays likely, a modulating role during dentinogenesis and amelogenesis by regulating the expression pattern of signalling molecules to achieve the proper structural formation of hard tissue matrices

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	FUSEA/FUBP1A/PUF60 complex
	FUBP1-FUSE complex is an essential component of a transcription molecular machinery that is necessary for tight regulation of expression of many key genes including MYC and CDKN1A

INTERACTION

DNA

RNA

small molecule

protein	binds to an upstream element of the MYC promoter and regulates the MYCmRNA level
	binds to FUSE, and PUF60, and forms a stable tripartite FUSEA/FUBP1A/PUF60 complex, which represses activated but not basal c-myc transcription after transcription initiation by delaying promoter escape
	Parkin substrate
	binds to noncoding strand FUSE
	interacts specifically with the 3prime UTR of NPM1 to repress translation
	interacting with USP22 (USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FUBP1)
	FUBP1 is a positive splicing regulatory factor of MDM2
	FUBP1 is also a strong positive splicing regulator that facilitates efficient splicing of the MDM2 pre-mRNA by binding its introns
	transactivator of MYC proto-oncogene transcription, with important roles in carcinogenesis
	FUBP1 and RUNX1 cooperate for the regulation of the expression of the oncogene KIT
	interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene KIT and amplifies cell proliferation
	FUBP1 upregulates the mRNA levels of two hexokinase genes, HK1 and HK2
	is a master transcriptional regulator of a subset of genes by interacting with a far upstream element (FUSE)
	FUBP1 utilizes its four articulated KH modules, which function cooperatively, for FUSE nucleotide binding

cell & other

REGULATION

Other

cleaved by executor caspases, during apoptosis at the caspase consensus site (DQPD(74) located within the classical bipartite nuclear localization signal sequence

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in human hepatocellular carcinoma (HCC) tumoral somatic mutation       CIC and FUBP1 mutations in oligodendrogliomas and in oligoastrocytomas tumoral       loss of function confers survival advantages to cells against metabolic stress and anti-cancer drugs tumoral     --over   in tongue squamous cell carcinoma (TSCC), correlated with TSCC cell proliferation and poor prognosis tumoral     --over   in clear cell renal cell carcinoma (ccRCC) tissues compared with adjacent noncancerous tissues tumoral     --over   in pancreatic cancer and associated with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	considered a novel biomarker for TSCC
	novel biomarker or an attractive treatment target of clear cell renal cell carcinoma (ccRCC)
Therapy target
	System Type Disorder Pubmed cancer urinary   attractive treatment target of clear cell renal cell carcinoma (ccRCC) cancer digestive liver promote tumor-relevant functions by at least partly employing the microtubule-destabilizing factor stathmin and represent a new potential target structure for HCC treatment cancer endocrine pancreas Targeting FUBP1 may be a novel therapeutic strategy to overcome the immunotherapy resistance in pancreatic cancer

ANIMAL & CELL MODELS